A cuff-sized window to the heart - JACC Adv.

Our most recent work on using noninvasive blood pressure waveforms at the brachial site to reconstruct left ventricular pressure has been published in [JACC Advances].

In cardiology, measuring heart pressure is essential for accurately diagnosing cardiovascular conditions. Currently, assessing left ventricular pressure requires an invasive catheterization procedure in a specialized lab, where a cardiologist threads a catheter directly into the patient’s heart. Until now, there has been no true noninvasive alternative — doctors have instead relied on surrogate measures such as blood pressure or echocardiography to guide decisions, knowing these do not capture the gold-standard signal. We have developed a new method that uses a standard arm cuff combined with artificial intelligence to directly reconstruct heart pressure from a simple brachial measurement. This approach has been shown to accurately reproduce the pressure signals typically recorded inside the heart, enabling doctors to detect early signs of heart failure at the bedside. By merging artificial intelligence with deep physiological expertise, this breakthrough paves the way for safer, more accessible, and more effective monitoring and diagnostics in cardiology.